haemophilia
a) The main symptom of hemophilia is expel. Mild cases may go unnoticed until later in life, when they occur during surgery or after trauma. In more severe cases, serious bleeding may occur without any cause. Internal bleeding may occur anywhere. Bleeding into joints is common.
b) (See table below for chart) Haemophilia A (clotting component VIII deficiency) is the most common form of the dis guild, occurring at round 1 in 5,00010,000 male births. Haemophilia B (factor IX deficiency) occurs at about 1 in about 20,00034,000 male births. It is very unlikely for a female to be affected
c) Current research beas and intercessions under analysis include: Recombinant factor VIII factortically engineered to avoid risks of disease transmission by infusion and also gene therapy.
d) Direct Mutation Testing
For Hemophilia A and B, it is possible to look for mutations within the gene. This approach is called look at DNA interrogatory and is the most accurate method for identifying common carriers. A blood sample from the male family member with hemophilia is analyse first. In about 98% of cases, a mutation send word be identified. Next, a blood sample from the woman desiring carrier examen is obtained, and her DNA is checked for the specific mutation.
Such interrogation is performed at specialized laboratories. Results are generally available in several weeks.Â
Linkage (Indirect) Testing
In some cases of Hemophilia A and Hemophilia B, a mutation cannot be identified. However, it may be possible to use indirect or linkage tests to look on the gene carrier status of females by tracking the gene in the family. Blood samples are obtained from the male with hemophilia and early(a) family members. Patterns of linked DNA in the person with hemophilia are compared to the DNA in family members to check for the same pattern. Linkage testing is not as accurate as direct testing and does not provide information for all families.
e) The main treatment for hemophilia is...If you want to get a full essay, order it on our website: Orderessay
If you want to get a full essay, wisit our page: write my essay .
No comments:
Post a Comment