Pharmacology

Pharmacology Research Paper Although currently available anticoagulants argon telling for the prevention and treatment of thromboembolic disorders, they assume several drawbacks. Low-molecular-weight heparins and fondaparinux expertness relieve oneself a predictable level of anti clotting and requires no coagulation supervise; however, they must be given parenterally, which leave them to be awkward for long-term use. Vitamin K antagonists, warfarin, is administered vocally, but produce a versatile anticoagulant response because of intake vitamin K and doubled do drugs interactions affect their metabolism (Augoustides, (2011). Consequently, coagulation monitoring and shop process adjustments are needed to ensure a curative level of anticoagulation is reached. This is troublesome for patients and health care professionals, and costly for the health care system. These limitations have encouraged the development of sunrise(prenominal) oral anticoagulants that marking throm bin or factor Xa and can be given in frosty doses without coagulation monitoring. This paper focuses on a new oral anticoagulant rivaroxaban or xarelto.

Mechanism of Action Rivaroxaban or xarelto prevents Factor Xa (FXa) at a central point in the coagulation cascade, where the external and intrinsic pathways meet, helping to modulate thrombin genesis. Preventing thrombin generation helps to inhibit clog up formation. Xarelto does not require a cofactor, such as antithrombin 3 for activity. Based on the studies, rivaroxaban demonstrate selective inhibition of some(prenominal) f! ree and clot-bound FXa as well as FXa in the factor X complex (XARELTO®, 2012). Pharmacokinetics Rivaroxaban, an oral channelise Factor Xa inhibitor, is an active complicated that exhibits high oral bioavailability, well-nigh 80%, and a fast onset and offset of action. plasm levels of rivaroxaban peak 23...If you hope to get a dependable essay, order it on our website: OrderEssay.net

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